A concise and highly enantioselective total synthesis of the akuammiline alkaloid (−)-
vincorine has been accomplished. A key element of the synthesis is a stereoselective …

An asymmetric total synthesis of the Akuammiline alkaloid (−)-vincorine (18 steps from 5-
methoxytryptamine, 5% overall yield) is described. The key steps include Pd-catalyzed direct …

The first total synthesis of the akuammiline alkaloid (±)-vincorine (6) has been accomplished
in about 1% overall yield in 31 steps. A concise assembly of the core 1, 2-disubstituted 1, 2 …

The akuammiline alkaloids are a structurally diverse class of bioactive natural products
isolated from plants found in various parts of the world. A particularly challenging subset of …

A 1, 2, 3, 4-tetrahydro-9a, 4a-(iminoethano)-9 H-carbazole (4) is a central structural feature
of the Strychnos alkaloid minfiensine (1) and akuammiline alkaloids such as vincorine (5) …

Outlined herein is a novel and scalable synthesis of (−)‐vindorosine based on two key
transformations. A highly diastereoselective vinylogous Mannich addition of dioxinone …

Asymmetric syntheses of (+)-apovincamine (1a) and (+)-vincamine (2) are described.
Construction of the pentacyclic diene lactam 14, a pivotal intermediate for synthesis of the …

A new reductive strategy for the stereo-and regioselective synthesis of functionalized
isoquinuclidines has been developed. Pivoting on the chemoselective iridium (I)-catalyzed …

A concise and efficient total synthesis of the spermidine alkaloid (-)-isooncinotine
incorporating a 22-membered lactam ring is outlined. The approach is largely catalysis …

Polycyclic alkaloids bearing all-carbon quaternary centers possess a diversity of biological
activities and are challenging targets in natural product synthesis. The development of a …