Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …

While traditional cell culture methods have relied on growing cells as monolayers, three-
dimensional (3D) culture systems can provide a convenient in vitro model for the study of …

Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

The efficiency of clinical trials involving transplantation of multipotent mesenchymal stromal
cells (MSCs) is often insufficient due to harsh conditions present within the target tissue …

As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …

Mesenchymal stem cells (MSCs) are considered as primary candidates for cell-based
therapies due to their multiple effects in regenerative medicine. Pre-conditioning of MSCs …

Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …

Numerous methods have been reported for the fabrication of 3D multi-cellular spheroids and
their use in stem cell culture. Current methods typically relying on the self-assembly of …

Mesenchymal stem cells (MSCs) offer significant therapeutic promise for various
regenerative therapies. However, MSC-based therapy for injury exhibits low efficacy due to …

Mesenchymal stem cells (MSCs) are primary candidates in cell therapy and tissue
engineering and are being tested in clinical trials for a wide range of diseases. Originally …