KRAS and NOTCH1/2 Mutations are Associated With Pathologic and Clinical Outcomes in Localized Pancreatic Cancer Treated With Neoadjuvant Chemotherapy and …

AV Reddy, C Hill, S Sehgal, D Ding… - International Journal of …, 2021 - redjournal.org
Purpose/Objective (s) The role of radiation for pancreatic cancer remains controversial with
heterogeneous clinical response. Characterization of molecular biomarkers that predict …

[HTML][HTML] Impact of somatic mutations on clinical and pathologic outcomes in borderline resectable and locally advanced pancreatic cancer treated with neoadjuvant …

AV Reddy, CS Hill, S Sehgal, D Ding… - Radiation Oncology …, 2021 - ncbi.nlm.nih.gov
Purpose The purpose of this study was to determine if somatic mutations are associated with
clinical and pathologic outcomes in patients with borderline resectable pancreatic cancer …

Pathway Mutations are Associated with Clinical Outcomes in Localized Pancreatic Cancer Treated with Neoadjuvant Chemoradiation Followed by Surgery

J Wang, T Lin, AV Reddy, C Hill, S Sehgal… - International Journal of …, 2023 - redjournal.org
Purpose/Objective (s) The purpose of this study was to determine if mutations in biological
pathways are associated with clinical outcomes in patients with localized pancreatic cancer …

Characterization of DNA Damage Response-Associated Somatic Mutations in Borderline Resectable and Locally Advanced Pancreatic Cancer

V Madan, TA Lin, AV Reddy, C Hill… - International Journal of …, 2023 - redjournal.org
Purpose/Objective (s) The role of radiation for pancreatic cancer remains controversial, with
recent studies showing conflicting results, highlighting the need to develop biomarkers of …

Comprehensive Genomic Analysis Stratified by KRAS Status in Patients with Pancreatic Adenocarcinoma and Its Prognostic Significance

J Kim, R Kumar, L Hathout, SK Jabbour… - International Journal of …, 2023 - redjournal.org
Purpose/Objective (s) KRAS mutations (MUT) are one of the major drivers in pancreatic
ductal adenocarcinoma (PDA) with over 90% of patients having alterations. However, the …

KRAS mutation status in the prediction of pancreatic tumor response after neoadjuvant systemic therapy and magnetic resonance-guided SBRT.

A Jethanandani, NA Hanson, I Ogobuiro, G Simpson… - 2024 - ascopubs.org
709 Background: Stereotactic body radiotherapy (SBRT) has been incorporated into multi-
modality treatment of locally advanced and borderline resectable pancreatic ductal …

Impact of KRAS alterations in localized pancreatic cancer (PC).

AV Shreenivas, K Annunzio, M Kamgar, S Chakrabarti… - 2021 - ascopubs.org
431 Background: Patients (pts) with localized PC do not routinely undergo comprehensive
genomic profiling (CGP) unless they develop recurrent or metastatic disease. KRAS is the …

Impact of neoadjuvant chemoradiation on pathologic response in patients with localized pancreatic cancer

D Wittmann, WA Hall, KK Christians, CA Barnes… - Frontiers in …, 2020 - frontiersin.org
Introduction/Background: Multimodal neoadjuvant therapy has resulted in increased rates of
histologic response in pancreatic tumors and adjacent lymph nodes. The biologic …

Neoadjuvant Chemotherapy and Stereotactic Body Radiation Therapy in Patients with Early Onset Pancreatic Cancer: Clinical Outcomes and Toxicity

S Sehgal, AV Reddy, C Hill, TA Lin, L Zheng… - International Journal of …, 2022 - redjournal.org
Purpose/Objective (s) Little is known on optimal management of patients with early onset
pancreatic cancer (EOPC), including the role of radiation therapy. As such, we report on a …

Impact of neoadjuvant chemoradiation on outcomes for patients with localized pancreatic cancer: a multi-institutional analysis

EP Ward, A Paniccia, M Aldakkak, WA Hall… - HPB, 2021 - hpbonline.org
Background: Although neoadjuvant therapy for pancreatic cancer (PC) is becoming more
widely accepted, the role of neoadjuvant chemoradiation (cXRT) remains controversial. We …