[HTML][HTML] Genetically predicted serum testosterone and risk of gynecological disorders: a Mendelian randomization study

B Zhao, Z Wang, D Liu, S Zhang - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Testosterone plays a key role in women, but the associations of serum
testosterone level with gynecological disorders risk are inconclusive in observational …

[HTML][HTML] Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Z Li, M Wang, M Hua, Z Wang, Y Ying, Z Zhang… - Discover Oncology, 2023 - Springer
Objective Previous observational studies have explored the correlation between
testosterone and cancer risk. However, the causal association between testosterone and …

Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation

S Yuan, L Wang, J Sun, L Yu, X Zhou… - International journal …, 2022 - academic.oup.com
Background Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been
associated with many diseases in observational studies; however, the causality of …

[HTML][HTML] Genetically predicted testosterone and cancers risk in men: a two-sample Mendelian randomization study

J Chang, Y Wu, S Zhou, Y Tian, Y Wang, J Tian… - Journal of Translational …, 2022 - Springer
Objective In observational studies, testosterone has been reported to be associated with
some types of cancers. However, the direction and magnitude of the causal association …

Maternal testosterone and offspring birth weight: a mendelian randomization study

BK Zheng, XY Sun, J Xian, PP Niu - The Journal of Clinical …, 2022 - academic.oup.com
Context Evidence has shown maternal androgen levels in both the general population and
populations with hyperandrogenic disorders are inversely associated with offspring birth …

[HTML][HTML] Genetic analyses implicate complex links between adult testosterone levels and health and disease

JT Leinonen, N Mars, LE Lehtonen… - Communications …, 2023 - nature.com
Background Testosterone levels are linked with diverse characteristics of human health, yet,
whether these associations reflect correlation or causation remains debated. Here, we …

[HTML][HTML] Body composition and testosterone in men: a Mendelian randomization study

Y Ikehata, T Hachiya, T Kobayashi, H Ide… - Frontiers in …, 2023 - frontiersin.org
Background Testosterone is an essential sex hormone that plays a vital role in the overall
health and development of males. It is well known that obesity decreases testosterone …

Genetically predicted testosterone and cardiovascular risk factors in men: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study

J Zhao, C Jiang, TH Lam, B Liu… - International journal …, 2014 - academic.oup.com
Background Observationally lower testosterone is associated with an unhealthier
cardiovascular (CVD) risk profile, but this association is open to confounding and reverse …

[HTML][HTML] New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study

C Jiang, Y Wang, W Yang, X Yang - Frontiers in Endocrinology, 2023 - frontiersin.org
Objective Type 2 diabetes mellitus (T2DM) is an endocrine-related disease with an
increasing incidence worldwide. Male sexual dysfunction is common in diabetic patients …

[HTML][HTML] Sex-specific associations of testosterone and genetic factors with health span

X Zhao, S Liang, N Wang, T Hong… - Frontiers in …, 2021 - frontiersin.org
Background Previous studies have suggested associations between testosterone, genetic
factors, and a series of complex diseases, but the associations with the lifespan phenotype …