Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails

H Ma, H Zong, J Liu, Y Yue, Y Ke, Y Liao… - Acta Pharmacologica …, 2023 - nature.com
The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants poses challenges to the effectiveness of neutralizing antibodies. Rational design …

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

L Li, M Gao, P Jiao, S Zu, Y Deng, D Wan, Y Cao… - Cell & Bioscience, 2022 - Springer
Background Neutralizing antibodies are approved drugs to treat coronavirus disease-2019
(COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS …

Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV

W Jiang, J Wang, S Jiao, C Gu, W Xu, B Chen, R Wang… - MAbs, 2021 - Taylor & Francis
The global pandemic of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in widespread social and economic disruption …

[HTML][HTML] Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants

J Lu, Q Yin, R Pei, Q Zhang, Y Qu, Y Pan, L Sun, D Gao… - Virologica Sinica, 2022 - Elsevier
Multiple new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have constantly emerged, as the delta and omicron variants, which have developed …

Dual monoclonal antibodies on Sars-Cov-2 Alpha and delta variants: clinical and virological efficacy

VM Ferré, N Peiffer-Smadja, L Kramer… - Microbiology …, 2022 - Am Soc Microbiol
Monoclonal antibodies (MAbs) targeting the Spike glycoprotein of SARS-CoV-2 is a key
strategy to prevent severe COVID-19. Here, the efficacy of two monoclonal antibody …

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN. 1 and other variants

MS Piepenbrink, AM Khalil, A Chang, A Mostafa… - bioRxiv, 2024 - biorxiv.org
SARS-CoV-2 continues to be a public health burden, driven in-part by its continued
antigenic diversification and resulting emergence of new variants. While increasing herd …

A potent and protective human neutralizing antibody against SARS-CoV-2 variants

S Shan, CK Mok, S Zhang, J Lan, J Li, Z Yang… - Frontiers in …, 2021 - frontiersin.org
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge and spread around the world, antibodies and vaccines to confer broad and potent …

Characterization of a Broadly Neutralizing Monoclonal Antibody against SARS-CoV-2 Variants

TS Zakir, T Meng, LCP Carmen, JJH Chu, RTP Lin… - Viruses, 2022 - mdpi.com
The constant mutation of SARS-CoV-2 has led to the emergence of new variants, which call
for urgent effective therapeutic interventions. The trimeric spike (S) protein of SARS-CoV-2 is …

Antibody cocktail exhibits broad neutralization activity against SARS-CoV-2 and SARS-CoV-2 variants

Y Qu, X Zhang, M Wang, L Sun, Y Jiang, C Li, W Wu… - Virologica Sinica, 2021 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated multiple
variants resistant to therapeutic antibodies. In this study, 12 high-affinity antibodies were …

SARS-CoV-2 E484K mutation narrative review: epidemiology, immune escape, clinical implications, and future considerations

WT Yang, WH Huang, TL Liao, TH Hsiao… - Infection and Drug …, 2022 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the
world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a …