Distinct microRNA signature in human serum and germline after childhood trauma

A Jawaid, M Kunzi, M Mansoor, ZY Khan, A Abid… - MedRxiv, 2020 - medrxiv.org
Traumatic experiences during childhood can persistently alter mental and physical health in
humans and have been implicated in transmission of symptoms to the progeny in animal …

Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling

A Payton, J Clark, L Eaves, HP Santos Jr… - Reproductive …, 2020 - Elsevier
Birth weight (BW) represents an important clinical and toxicological measure, indicative of
the overall health of the newborn as well as potential risk for later-in-life outcomes. BW can …

Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT …

EM Sedlmeier, DM Meyer, L Stecher, M Sailer… - BMC Molecular and Cell …, 2021 - Springer
Background Previously, we revealed sexually dimorphic mRNA expression and
responsiveness to maternal dietary supplementation with n-3 long-chain polyunsaturated …

Bioactive compounds in mothers milk affecting offspring outcomes: A narrative review

B Gregg, L Ellsworth, G Pavela, K Shah… - Pediatric …, 2022 - Wiley Online Library
Background Compared to the exhaustive study of transgenerational programming of obesity
and diabetes through exposures in the prenatal period, postnatal programming mechanisms …

Placental microRNAs relate to early childhood growth trajectories

EM Kennedy, K Hermetz, A Burt, D Pei, DC Koestler… - Pediatric …, 2023 - nature.com
Background Poor placental function is a common cause of intrauterine growth restriction,
which in turn is associated with increased risks of adverse health outcomes. Our prior work …

A history of preterm delivery is associated with aberrant postpartal MicroRNA expression profiles in mothers with an absence of other pregnancy-related complications

I Hromadnikova, K Kotlabova, L Krofta - International Journal of Molecular …, 2021 - mdpi.com
This prospective cross-sectional case-control study investigated the postpartal gene
expression of microRNAs associated with diabetes/cardiovascular/cerebrovascular …

[HTML][HTML] Single-cell RNA sequencing reveals placental response under environmental stress

E Van Buren, D Azzara, J Rangel-Moreno… - Nature …, 2024 - nature.com
The placenta is crucial for fetal development, yet the impact of environmental stressors such
as arsenic exposure remains poorly understood. We apply single-cell RNA sequencing to …

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR …

L Guo, SQ Tsai, NE Hardison, AH James… - Placenta, 2013 - Elsevier
INTRODUCTION: This study focuses on the implementation of modulated modularity
clustering (MMC) a new cluster algorithm for the identification of molecular signatures of …

[HTML][HTML] Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands

A Kupsco, JJ Lee, D Prada, D Valvi, L Hu… - Environment …, 2022 - Elsevier
Abstract Background/Aims Early life exposures to marine contaminants can adversely
impact child health but modes of action are unclear. Human milk contains extracellular …

Identification of candidate immune system microRNAs differentially found in colostrum and milk exosomes

P Verma, N Mohanty, B Pruseth, S Sahoo, A Katiyar… - …, 2022 - ingentaconnect.com
Background: The fetus grows in a sterile womb environment. After birth, the newborn
immune system has two immediate hurdles to clear. First immediate suppression of the …