Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: analysis of a North American cohort

AN Ananthakrishnan, H Huang… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically
mediated diseases with a progressive relapsing remitting course. There is considerable …

[HTML][HTML] Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across …

SK Yang, M Hong, W Zhao, Y Jung, J Baek, N Tayebi… - Gut, 2014 - gut.bmj.com
Objective Crohn9s disease (CD) is an intractable inflammatory bowel disease (IBD) of
unknown cause. Recent meta-analysis of the genome-wide association studies (GWAS) and …

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine

P Goyette, C Labbé, TT Trinh, RJ Xavier… - Annals of …, 2007 - Taylor & Francis
Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel
diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is …

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

JC Barrett, S Hansoul, DL Nicolae, JH Cho, RH Duerr… - Nature …, 2008 - nature.com
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

Determinants of IBD heritability: genes, bugs, and more

W Turpin, A Goethel, L Bedrani… - Inflammatory bowel …, 2018 - academic.oup.com
Defining the etiology of inflammatory bowel disease (IBD) continues to elude researchers, in
part due to the possibility that there may be different triggers for a spectrum of disease …

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

BD Ye, DPB McGovern - Expert review of clinical immunology, 2016 - Taylor & Francis
Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory
bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations …

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

CW Lees, J Satsangi - Expert review of gastroenterology & …, 2009 - Taylor & Francis
Epidemiological data, detailed molecular studies and recent genome-wide association
studies strongly suggest that ulcerative colitis (UC) and Crohn's disease (CD) are related …

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

KM De Lange, L Moutsianas, JC Lee, CA Lamb… - Nature …, 2017 - nature.com
Genetic association studies have identified 215 risk loci for inflammatory bowel disease,,,,,,,,
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …

[PDF][PDF] IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with …

C Giallourakis, M Stoll, K Miller, J Hampe… - The American Journal of …, 2003 - cell.com
Inflammatory bowel disease (IBD) refers to complex chronic relapsing autoimmune
disorders of the gastrointestinal tract that have been traditionally classified into Crohn …