Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we
investigated 50 previously reported susceptibility loci in a German sample of individuals with …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

Background & Aims Genome-wide association studies have identified 200 inflammatory
bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative …

Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …

Technological advances in the large scale analysis of human genetics have generated
profound insights into possible genetic contributions to chronic diseases including the …

Genome-wide association studies efficiently and powerfully assay common genetic
variation. The application of these studies to Crohn's disease has provided insight into the …

Crohn's disease and ulcerative colitis constitute two major subgroups of inflammatory bowel
diseases (IBD), a group of complex polygenic diseases characterized by chronic and …

Advancements in human genetics now poise the field to illuminate the pathophysiology of
complex genetic disease. In particular, genome-wide association studies (GWAS) have …

The idiopathic inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis
(UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin …

Background IBD5, IL23R, and ATG16L1 genetic variations are established Crohn's disease
(CD) risks alleles. We evaluated these in a population-based case-control study within a …