Long non‐coding RNAs in cancer: another layer of complexity

JC de Oliveira, LC Oliveira, C Mathias… - The journal of gene …, 2019 - Wiley Online Library
We review the most well characterized long non‐coding RNAs (lncRNAs) with important
roles in hallmarks of cancer, additionally including lncRNAs with a higher potential for …

Long non-coding RNA: dual effects on breast cancer metastasis and clinical applications

QY Huang, GF Liu, XL Qian, LB Tang, QY Huang… - Cancers, 2019 - mdpi.com
As a highly heterogeneous malignancy, breast cancer (BC) has become the most significant
threat to female health. Distant metastasis and therapy resistance of BC are responsible for …

Long noncoding RNAs in cancer cells

DH Bach, SK Lee - Cancer letters, 2018 - Elsevier
Long noncoding RNA (lncRNA) has recently been investigated as key modulators that
regulate many biological processes in human cancers via diverse mechanisms. LncRNAs …

Post-transcriptional regulation of long noncoding RNAs in cancer

X Shi, M Sun, Y Wu, Y Yao, H Liu, G Wu, D Yuan… - Tumor Biology, 2015 - Springer
It is a great surprise that the genomes of mammals and other eukaryotes harbor many
thousands of long noncoding RNAs (lncRNAs). Although these long noncoding transcripts …

Emerging roles of long non‐coding RNA in cancer

A Sanchez Calle, Y Kawamura, Y Yamamoto… - Cancer …, 2018 - Wiley Online Library
Since comprehensive analysis of the mammalian genome revealed that the majority of
genomic products are transcribed in long non‐coding RNA (lnc RNA), increasing attention …

Role of long non-coding RNAs (lncRNAs) in cancer: from subcellular localization to nanoparticles (NPs)-mediated targeted regulation

C Wei, Y Xu, Q Shen, R Li, X Xiao, PE Saw… - … Therapy-Nucleic Acids, 2023 - cell.com
Long non-coding RNAs (lncRNAs) are a class of RNA transcripts more than 200 nucleotides
in length that play crucial roles in cancer development and progression. With the rapid …

Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?

DJ Hanly, M Esteller… - … Transactions of the …, 2018 - royalsocietypublishing.org
Of the diverse array of putative molecular and biological functions assigned to long non-
coding RNAs (lncRNAs), one attractive perspective in epigenetic research has been the …

Non-coding RNAs, epigenetics, and cancer: tying it all together

HJ Ferreira, M Esteller - Cancer and Metastasis Reviews, 2018 - Springer
While only a small part of the human genome encodes for proteins, biological functions for
the so-called junk genome are increasingly being recognized through high-throughput …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Long noncoding RNAs: fine-tuners hidden in the cancer signaling network

S Zhao, X Zhang, S Chen, S Zhang - Cell death discovery, 2021 - nature.com
With the development of sequencing technology, a large number of long non-coding RNAs
(lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered …