Long non-coding RNAs and their implications in cancer epigenetics

FC Beckedorff, MS Amaral… - Bioscience …, 2013 - portlandpress.com
LncRNAs (long non-coding RNAs) have emerged as key molecular players in the regulation
of gene expression in different biological processes. Their involvement in epigenetic …

Long non-coding RNAs as novel therapeutic targets in cancer

G Lavorgna, R Vago, M Sarmini, F Montorsi… - Pharmacological …, 2016 - Elsevier
Thanks to impressive technology advancements, pervasive expression of non-coding RNAs
(ncRNAs) has been recently identified in the genome of numerous cancers. Long ncRNAs …

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

Z Ma, YY Wang, HW Xin, L Wang, F Arfuso… - The international journal …, 2019 - Elsevier
Long non-coding RNAs (lncRNAs) are a novel class of gene regulators playing multifaceted
roles in physiological processes as well as pathological conditions such as cancer. Cancer …

Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

[HTML][HTML] Long non-coding RNAs in breast cancer metastasis

P Mondal, SM Meeran - Non-coding RNA research, 2020 - Elsevier
Breast cancer is the leading cause of cancer-related death among women. Recurrence of
primary tumor and metastasis to distant body parts are major causes of breast cancer …

Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function

CR Cabanski, NM White, HX Dang, JM Silva-Fisher… - RNA biology, 2015 - Taylor & Francis
A growing number of gene-centric studies have highlighted the emerging significance of
lncRNAs in cancer. However, these studies primarily focus on a single cancer type …

Small and long non-coding RNAs: novel targets in perspective cancer therapy

C Han Li, Y Chen - Current genomics, 2015 - ingentaconnect.com
Non-coding RNA refers to a large group of endogenous RNA molecules that have no protein
coding capacity, while having specialized cellular and molecular functions. They possess …

LncRNA-mediated regulation of cell signaling in cancer

WX Peng, P Koirala, YY Mo - Oncogene, 2017 - nature.com
To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …

[HTML][HTML] Roles of oncogenic long non-coding RNAs in cancer development

H Do, W Kim - Genomics & informatics, 2018 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200
nucleotides and cannot be translated into protein. Several studies have demonstrated that …

Exploring the roles of lncRNAs in GBM pathophysiology and their therapeutic potential

CT Stackhouse, GY Gillespie, CD Willey - Cells, 2020 - mdpi.com
Glioblastoma (GBM) remains the most devastating primary central nervous system
malignancy with a median survival of around 15 months. The past decades of research have …