Cornuside is an iridoid glycoside from Cornus officinalis, with the activities of anti-
inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the …

Anti‐Alzheimer's disease (AD) drugs can only change the symptoms of cognitive impairment
in a short time but cannot prevent or completely cure AD. Thus, a more effective drug is …

Background Glial activation and neuroinflammation play a crucial role in the pathogenesis
and development of Alzheimer's disease (AD). The receptor for advanced glycation end …

Abstract Ethnopharmacological relevance Cornus officinalis Sieb. et Zucc., traditional
Chinese medicine, has been widely used in the treatment of dementia. Cornel iridoid …

Neuroinflammation is a predisposing factor for several neurodegenerative diseases. The
purpose of this study was to evaluate the protective effect of madecassoside (MA) in …

Traumatic brain injury leads to problems with movement and cognitive deficits and has a
high mortality rate. Cornel iridoid glycoside, the active ingredient of Cornus officinalis, has …

Background Cognitive deficit is the main clinical feature of Alzheimer's disease (AD), and the
massive death of neuronal cells is the leading cause of cognitive deficits. So, there is an …

Reducing β amyloid‐(Aβ‐) induced microglial activation is believed to be effective in treating
Alzheimer's disease (AD). Microglia can be activated into classic activated state (M1 state) or …

Aging-related especially brain aging-related diseases are heavy health care burdens
worldwide. Natural products with antioxidant and anti-inflammatory properties have been …

Background Targeted proteinopathy is involved in creating pharmacological agents that
protect against Alzheimer disease (AD). Cornel iridoid glycoside (CIG) is an effective …