Background The clinical trials community has a never-ending search for dependable and
reliable ways to improve clinical research. This exploration has led to considerable interest …

Adaptive designs can make clinical trials more flexible by utilising results accumulating in
the trial to modify the trial's course in accordance with pre-specified rules. Trials with an …

Adaptive designs for clinical trials permit alterations to a study in response to accumulating
data in order to make trials more flexible, ethical, and efficient. These benefits are achieved …

Objectives This review investigates characteristics of implemented adaptive design clinical
trials and provides examples of regulatory experience with such trials. Design Review of …

Recent draft Food and Drug Administration (FDA) guidelines on adaptive clinical trial design
and conduct provide a useful background for both academic and industry clinical research …

Adaptive designs are increasingly used in clinical trials. The Drug Information Association's
Adaptive Design Scientific Working Group (ADSWG) works to foster collaboration among …

There is considerable interest among pharmaceutical and other medical product developers
in adaptive clinical trials, in which knowledge learned during the course of a trial affects …

Adaptive designs allow planned modifications based on data accumulating within a study.
The promise of greater flexibility and efficiency stimulates increasing interest in adaptive …

In the last decade or so, interest in adaptive design clinical trials has gradually been directed
towards their use in regulatory submissions by pharmaceutical drug sponsors to evaluate …

Background/aims: The increasing cost of the drug development process has seen interest in
the use of adaptive trial designs grow substantially. Accordingly, much research has been …