Chronic neuropathic and inflammatory pain is a major public health problem. Nociceptors
undergo sensitization, first in peripheral tissues then in the central nervous sytem, via …

The growing awareness of the critical role played by the innate and adaptive immune
systems in the mechanisms underlying chronic pain has prompted further research …

Chronic pain remains a public health problem and contributes to the ongoing opioid
epidemic. Current pain management therapies still leave many patients with poorly …

Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …

Pain is an unpleasant sensation associated with injury, inflammation, and infection. It has
been demonstrated that communication between immune cells and neurons plays a vital …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …

Chronic pain associated with joint disorders, such as rheumatoid arthritis (RA), osteoarthritis
(OA) and implant aseptic loosening (AL), is a highly debilitating symptom that impacts …

In rheumatology, chronic pain most often sets in after a musculoskeletal injury. Its
persistence is not always due to the progression of the initial injury, but in some cases to the …

Most autoimmune diseases are associated with pathological pain development.
Autoimmune diseases with pathological pain include complex regional pain syndrome …

One area that has emerged as a promising therapeutic target for the treatment and
prevention of chronic pain and opioid tolerance/hyperalgesia is the modulation of the central …