Nuclear factor erythroid 2-related factor-2 (Nrf2) antioxidant signaling is involved in liver
protection, but this generalization overlooks conflicting studies indicating that Nrf2 effects are …

Hepatic ischemia/reperfusion injury (IRI) is a critical component of hepatic surgery. Oxidative
stress has long been implicated as a key player in IRI. In this study, we examine the cell …

Background Nuclear factor erythroid 2–related factor 2 (Nrf2), a master regulator of the
antioxidant host defense, maintains the cellular redox homeostasis. Methods This study was …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

The transcription factor Nrf2 is a key regulator for hepatic induction of detoxifying enzymes,
antioxidative stress genes and Mrp efflux transporters. We aimed to investigate whether Nrf2 …

Methods Nrf2 KO and WT animals, and novel transgenic mice expressing a constitutively
active Nrf2 mutant in hepatocytes (AlbCre+/caNrf2+) and their littermate controls underwent …

Background Liver fibrosis, in which hepatocyte damage and inflammatory response play
critical roles, is a physiological response to chronic or iterative liver injury and can progress …

BACKGROUND AND PURPOSE Lithocholic acid (LCA), the most toxic bile acid, induces
cholestatic liver injury in rodents. We previously showed that LCA activates the oxidative …

Oxidative stress–mediated destruction of normal parenchymal cells during hepatic
inflammatory responses contributes to the pathogenesis of immune-mediated hepatitis and …

Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …