A large body of evidence suggests hepatic uptake transporters, organic anion‐transporting
polypeptides (OATPs), are of high clinical relevance in determining the pharmacokinetics of …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Membrane transporters play an important role in the absorption, distribution, clearance, and
elimination of drugs. Supported by the pharmacokinetics data in human, several transporters …

The American Association of Pharmaceutical Scientists/International Transporter
Consortium Joint Workshop on Drug Transporters in absorption, distribution, metabolism …

Pharmacokinetic drug-drug interactions (DDIs) are a major concern in drug development.
Drug transport, along with drug metabolism via cytochrome P450s (CYPs), is increasingly …

Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …

Nobody doubts the importance of organic anion transporting polypeptide (OATP) 1B1 and
1B3 in the clinical pharmacokinetics of substrate drugs. Based on the theory of …

Transporter‐mediated drug–drug interactions (DDIs) are among the most important of the
clinically relevant pharmacokinetic DDIs. We investigated the validity of a static prediction of …

Hepatic OATPs 1B1, 1B3 and 2B1, as well as P-gp, play important roles in regulating liver
uptake and biliary excretion of drugs. The intrinsic ethnic variability in OATP1B1-mediated …