Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach
K Peng, J Bacon, M Zheng, Y Guo, MZ Wang - Drug Metabolism and …, 2015 - ASPET
Hepatic OATPs 1B1, 1B3 and 2B1, as well as P-gp, play important roles in regulating liver
uptake and biliary excretion of drugs. The intrinsic ethnic variability in OATP1B1-mediated …
uptake and biliary excretion of drugs. The intrinsic ethnic variability in OATP1B1-mediated …
Rifampin-and silymarin-mediated pharmacokinetic interactions of exogenous and endogenous substrates in a transgenic OATP1b mouse model
BJ Bechtold, KD Lynch, VO Oyanna… - Molecular …, 2024 - ACS Publications
Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3, encoded by the SLCO
gene family of the solute carrier superfamily, are involved in the disposition of many …
gene family of the solute carrier superfamily, are involved in the disposition of many …
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney
H Kusuhara, Y Sugiyama - Drug metabolism and pharmacokinetics, 2009 - jstage.jst.go.jp
Transporters govern drug movement into and out of tissues, thereby playing an important
role in drug disposition in plasma and to the site of action. The molecular cloning of such …
role in drug disposition in plasma and to the site of action. The molecular cloning of such …
Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation
AT Nies, E Schaeffeler, M Schwab - Pharmacology & Therapeutics, 2022 - Elsevier
Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
Biomarkers for in vivo assessment of transporter function
Drug–drug interactions are a major concern not only during clinical practice, but also in drug
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …
Meta-analysis of expression of hepatic organic anion–transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue
J Badée, B Achour, A Rostami-Hodjegan… - Drug Metabolism and …, 2015 - ASPET
Organic anion–transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 transporters
play an important role in hepatic drug disposition. Recently, an increasing number of studies …
play an important role in hepatic drug disposition. Recently, an increasing number of studies …
Identification and evaluation of clinical substrates of organic anion transporting polypeptides 1B1 and 1B3
SJ McFeely, TK Ritchie, J Yu… - Clinical and …, 2019 - Wiley Online Library
Organic anion transporting polypeptides (OATPs) 1B1 and 1B3 facilitate the uptake of drugs
and endogenous compounds into the liver. In recent years, the impact of these transporters …
and endogenous compounds into the liver. In recent years, the impact of these transporters …
Prediction of pharmacokinetics and drug–drug interactions when hepatic transporters are involved
Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …
determining the systemic clearance for a number of widely prescribed drugs and an …
Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion …
Y Nozaki, S Izumi - Drug Metabolism and Pharmacokinetics, 2020 - Elsevier
Hepatic uptake mediated by organic anion transporting polypeptide (OATP) 1B1 and 1B3
can serve as a major elimination pathway for various anionic drugs and as a site of drug …
can serve as a major elimination pathway for various anionic drugs and as a site of drug …
Preincubation Time-Dependent, Long-Lasting Inhibition of Drug Transporters and Impact on the Prediction of Drug− Drug Interactions
Y Nozaki, S Izumi - Drug Metabolism and Disposition, 2023 - ASPET
Transporter-mediated drug− drug interaction (DDI) is of clinical concern, and the quantitative
prediction of DDIs is an indispensable part of drug development. Cell-based inhibition …
prediction of DDIs is an indispensable part of drug development. Cell-based inhibition …