Recent studies of membrane transporters have revealed their importance in determining the
pharmacokinetics of transporter substrates. When drug-drug interactions (DDIs) or genetic …

Transporters are membrane‐bound proteins that control the access of endogenous and
xenobiotics (drugs) to various sites in the human body. They influence drug …

Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …

Interindividual variation in drug response continues to pose a considerable challenge to
optimal drug therapy. Drug-metabolizing enzymes have been established as critical …

There has been remarkable progress during the past decade in understanding of how
genetic variations in drug metabolizing enzymes and transporters contribute to observed …

Bioavailability of orally administered drugs is partly determined by function of drug
transporters in the liver and intestine. Therefore, we explored adenosine triphosphate …

The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Members of the organic anion transporting polypeptide (OATP) family are responsible for the
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …

Quantitative prediction of complex drug-drug interactions (DDIs) involving hepatic
transporters and cytochromes P450 (P450s) is challenging. We evaluated the extent of DDIs …

The aim of precision medicine is to improve health care by tailoring drug treatment to
patientsL individual characteristics through the integration of knowledge explaining …