Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway

Q Tian, Y Guo, S Feng, C Liu, P He, J Wang… - Journal of …, 2022 - Springer
Background Neuroinflammation and neuronal apoptosis are closely associated with a poor
prognosis in patients with subarachnoid hemorrhage (SAH). We investigated the role of C–C …

[HTML][HTML] CCR1 activation promotes neuroinflammation through CCR1/TPR1/ERK1/2 signaling pathway after intracerebral hemorrhage in mice

J Yan, G Zuo, P Sherchan, L Huang, U Ocak, W Xu… - …, 2020 - Elsevier
The activation of CC chemokine receptor type 1 (CCR1) has been shown to be pro-
inflammatory in several animal models of neurological diseases. The objective of this study …

CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice

J Lin, Y Xu, P Guo, YJ Chen, J Zhou, M Xia… - Journal of translational …, 2023 - Springer
Background Owing to metabolic disequilibrium and immune suppression, intracerebral
hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of …

CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats

A Zhang, Y Liu, H Xu, Z Zhang, X Wang… - Stroke and Vascular …, 2023 - svn.bmj.com
Background and purpose CC motif chemokine ligand 17 (CCL17) presents an important role
in immune regulation, which is critical in the pathophysiology of brain injury after …

Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in …

S Deng, P Jin, P Sherchan, S Liu, Y Cui… - Journal of …, 2021 - Springer
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated
with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …

Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

J Yan, W Xu, C Lenahan, L Huang, U Ocak… - Fluids and Barriers of …, 2022 - Springer
Background C–C chemokine receptor type 1 (CCR1) and its endogenous ligand, CCL5,
participate in the pathogenesis of neuroinflammatory diseases. However, much remains …

Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage

SH Ahn, JPJ Savarraj, K Parsha… - Journal of …, 2019 - Springer
Background Inflammatory mechanism has been implicated in delayed cerebral ischemia
(DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification of …

[HTML][HTML] Inhibition of caspase-1-mediated inflammasome activation reduced blood coagulation in cerebrospinal fluid after subarachnoid haemorrhage

Y Fang, X Wang, J Lu, H Shi, L Huang, A Shao… - …, 2022 - thelancet.com
Background Neuroinflammation and blood coagulation responses in cerebrospinal fluid
(CSF) contribute to the poor outcome associated with subarachnoid haemorrhage (SAH) …

Chemokine CCL2 contributes to BBB disruption via the p38 MAPK signaling pathway following acute intracerebral hemorrhage

F Guo, D Xu, Y Lin, G Wang, F Wang, Q Gao… - The FASEB …, 2020 - Wiley Online Library
Intracerebral hemorrhage (ICH) remains a devastating type of stroke that lacks an effective
treatment. Recent evidence has demonstrated that CCL2 is involved in the blood‐brain …

Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage

ZV Zheng, J Chen, H Lyu, SYE Lam, G Lu… - Stroke and Vascular …, 2022 - svn.bmj.com
Background and purpose Signal transducer and activator of transcription 3 (STAT3) may
contribute to the proinflammation in the central nervous system diseases by modulating the …