Despite important recent advances, a full understanding of the (genetic) etiology of
Alzheimer's disease (AD) is still a long way off. Large collaborative efforts are ongoing, as …

Alzheimer's dementia commonly impacts the health of older adults and lacks any
preventative therapy. While Alzheimer's dementia risk has a substantial genetic component …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four
genes have been established to either cause early-onset autosomal-dominant AD (APP …

Alzheimer's disease (AD) is the most common form of dementia, which affects more than 35
million people worldwide with increasing tendency. Satisfying therapies and prevention are …

Alzheimer's disease (AD) is the most common form of dementia, accounting for 60–80% of
all dementia cases [1]. Due to variation in age at onset (AAO), AD is classified as either early …

Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …

The strategies of classifying APP, PSEN1, and PSEN2 variants varied substantially in the
previous studies. We aimed to re-evaluate these variants systematically according to the …

Like several neurodegenerative disorders, such as Prion and Parkinson diseases,
Alzheimer's disease (AD) is characterized by spreading mechanism of aggregated proteins …

Alzheimer's disease is a complex and heterogeneous, severe neurodegenerative disorder
and the predominant form of dementia, characterized by cognitive disturbances, behavioral …

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and
together with polygenetic risk stratification can contribute towards planning of feasible and …