Translational research on the way to effective therapy for Alzheimer disease

RN Rosenberg - Archives of general psychiatry, 2005 - jamanetwork.com
Context Alzheimer disease (AD) is a major public health issue with a prediction of 12 million
Americans being affected by 2025 from the present 4 million. Molecular and genetic findings …

Alzheimer's disease: an updated overview of its genetics

J Andrade-Guerrero, A Santiago-Balmaseda… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

Genome-wide association analysis of age-at-onset in Alzheimer's disease

MI Kamboh, MM Barmada, FY Demirci, RL Minster… - Molecular …, 2012 - nature.com
The risk of Alzheimer's disease (AD) is strongly determined by genetic factors and recent
genome-wide association studies (GWAS) have identified several genes for the disease risk …

Recent progress in Alzheimer's disease research, part 2: genetics and epidemiology

M Robinson, BY Lee, FT Hane - Journal of Alzheimer's …, 2017 - content.iospress.com
This is the second part of a three-part review series reviewing the most important advances
in Alzheimer's disease (AD) research since 2010. This review covers the latest research on …

Molecular genetics of Alzheimer's disease

P Pastor, AM Goate - Current psychiatry reports, 2004 - Springer
Alzheimer disease (AD) is the most common cause of dementia. In the past decade, many
advances in the understanding of the etiology of AD have been reported. Familial early …

[HTML][HTML] Epigenetic alterations in Alzheimer's disease

JV Sanchez-Mut, J Gräff - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

[HTML][HTML] Alzheimer's disease: from genetic variants to the distinct pathological mechanisms

Q Sun, N Xie, B Tang, R Li, Y Shen - Frontiers in Molecular …, 2017 - frontiersin.org
Being the most common cause of dementia, AD is a polygenic and neurodegenerative
disease. Complex and multiple factors have been shown to be involved in its pathogenesis …

[HTML][HTML] Genetics of Alzheimer's disease

PG Ridge, MTW Ebbert, JSK Kauwe - BioMed research international, 2013 - hindawi.com
Alzheimer's disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease-altering treatments. It is a complex disorder …

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

DK Lahiri, MR Farlow, K Sambamurti… - Current drug …, 2003 - ingentaconnect.com
Alzheimer's disease (AD), a progressive, degenerative disorder of the brain, is believed to
be the most common cause of dementia amongst the elderly. AD is characterized by the …

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer's disease risk

IE Jansen, JE Savage, K Watanabe, J Bryois… - Biorxiv, 2018 - biorxiv.org
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with more than 35
million people affected worldwide, and no curative treatment currently available. AD is highly …