Transcription factor–DNA binding: beyond binding site motifs
S Inukai, KH Kock, ML Bulyk - Current opinion in genetics & development, 2017 - Elsevier
Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
Mechanisms of transcription factor selectivity
The initiation of transcription is regulated by transcription factors (TFs) binding to DNA
response elements (REs). How do TFs recognize specific binding sites among the many …
response elements (REs). How do TFs recognize specific binding sites among the many …
[HTML][HTML] Low-affinity binding sites and the transcription factor specificity paradox in eukaryotes
JF Kribelbauer, C Rastogi… - Annual review of cell …, 2019 - annualreviews.org
Eukaryotic transcription factors (TFs) from the same structural family tend to bind similar DNA
sequences, despite the ability of these TFs to execute distinct functions in vivo. The cell …
sequences, despite the ability of these TFs to execute distinct functions in vivo. The cell …
[HTML][HTML] Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
[HTML][HTML] DNA-binding specificities of human transcription factors
Although the proteins that read the gene regulatory code, transcription factors (TFs), have
been largely identified, it is not well known which sequences TFs can recognize. We have …
been largely identified, it is not well known which sequences TFs can recognize. We have …
Transcription factors: specific DNA binding and specific gene regulation
Specific recognition of cis-regulatory regions is essential for correct gene regulation in
response to developmental and environmental signals. Such DNA sequences are …
response to developmental and environmental signals. Such DNA sequences are …
Generic binding sites, generic DNA‐binding domains: where does specific promoter recognition come from?
A transcription reaction relies on the specific recognition of cis‐regulatory regions containing
short DNA motifs. Such sequences are bound by transcription factors (TFs) involved in the …
short DNA motifs. Such sequences are bound by transcription factors (TFs) involved in the …
A widespread role of the motif environment in transcription factor binding across diverse protein families
Transcriptional regulation requires the binding of transcription factors (TFs) to short
sequence-specific DNA motifs, usually located at the gene regulatory regions. Interestingly …
sequence-specific DNA motifs, usually located at the gene regulatory regions. Interestingly …
Unraveling determinants of transcription factor binding outside the core binding site
Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control
of gene expression. Despite many advances in the characterization of sequence motifs …
of gene expression. Despite many advances in the characterization of sequence motifs …
[HTML][HTML] The human transcription factors
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …
transcription, forming a complex system that guides expression of the genome. Despite keen …