We modeled the viral dynamics of 13 untreated patients infected with severe acute
respiratory syndrome‐coronavirus 2 to infer viral growth parameters and predict the effects …

The scientific community is focused on developing antiviral therapies to mitigate the impacts
of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated …

Background Development of an effective antiviral drug for Coronavirus Disease 2019
(COVID-19) is a global health priority. Although several candidate drugs have been …

Repurposed drugs that are safe and immediately available constitute a first line of defense
against new viral infections. Despite limited antiviral activity against SARS-CoV-2, several …

To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The
number of clinical trials that can be performed is limited. We developed mathematical …

The characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viral kinetics in hospitalized patients and its association with mortality is unknown. We …

Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …

Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a
mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques …

There is a rapidly expanding literature on the in vitro antiviral activity of drugs that may be
repurposed for therapy or chemoprophylaxis against severe acute respiratory syndrome …

The health emergency caused by the recent Covid‐19 pandemic highlights the need to
identify effective treatments against the virus causing this disease (SARS‐CoV‐2). The first …