Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune
system (immunosenescence) may be associated with disease onset or drive progression …

Aim: Accumulating evidence links epigenetic age to diseases and age-related conditions,
but little is known about its association with multiple sclerosis (MS). Materials & methods: We …

Objectives Epigenetic modifications are closely linked with aging, but their relationship with
cognition remains equivocal. Given known sex differences in epigenetic aging, we explored …

Aging is a significant risk factor for various human disorders, and DNA methylation clocks
have emerged as powerful tools for estimating biological age and predicting health‐related …

Background Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of
the central nervous system (CNS) characterized by irreversible disability at later progressive …

Multiple sclerosis (MS) is most likely to adopt a progressive clinical course during middle
age or beyond, and the number of older adults with MS is steadily increasing. Developing …

Major depressive disorder (MDD) is known to cause significant disability. Genome-wide
DNA methylation (DNAm) profiles can be used to estimate biological aging and as …

Background Little is known about the role of DNA methylation (DNAm) epigenetic age
acceleration in cognitive decline. Using a twin study design, we examined whether DNAm …

Background Chronological age is associated with disability accumulation in multiple
sclerosis (MS). Biological age may give more precise estimates of aging pathways …

Background Immunosenescence (ISC) describes age-related changes in immune-system
composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition …