Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo
W Jacob, R Marsch, G Marsicano, B Lutz… - Neurobiology of learning …, 2012 - Elsevier
The cannabinoid receptor type 1 (CB1) is abundantly expressed in the central nervous
system where it negatively controls the release of several neurotransmitters. CB1 activity …
system where it negatively controls the release of several neurotransmitters. CB1 activity …
CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice
A Cannich, CT Wotjak, K Kamprath… - Learning & …, 2004 - learnmem.cshlp.org
Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term
extinction of auditory-cued fear memory. The molecular mechanisms underlying this function …
extinction of auditory-cued fear memory. The molecular mechanisms underlying this function …
Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes
K Kamprath, G Marsicano, J Tang… - Journal of …, 2006 - Soc Neuroscience
The interplay between fear expression and fear extinction provides an important prerequisite
for adequate coping with aversive encounters. Current models propose that extinction of …
for adequate coping with aversive encounters. Current models propose that extinction of …
Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation
Recent studies show contradictory results regarding the contribution of endocannabinoids in
fear memory formation and long-term synaptic plasticity. In this study, we investigated the …
fear memory formation and long-term synaptic plasticity. In this study, we investigated the …
CB2 cannabinoid receptor knockout in mice impairs contextual long‐term memory and enhances spatial working memory
Y Li, J Kim - Neural plasticity, 2016 - Wiley Online Library
Neurocognitive effects of cannabinoids have been extensively studied with a focus on CB1
cannabinoid receptors because CB1 receptors have been considered the major …
cannabinoid receptors because CB1 receptors have been considered the major …
Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear …
M Maćkowiak, A Chocyk, D Dudys, K Wedzony - Neuroscience, 2009 - Elsevier
We investigated the role of CB1 receptors in hippocampal-dependent memory consolidation
mediated by polysialylated neural cell adhesion molecule (PSA-NCAM) during contextual …
mediated by polysialylated neural cell adhesion molecule (PSA-NCAM) during contextual …
Chronic cannabinoid administration in vivo compromises extinction of fear memory
HC Lin, SC Mao, PS Chen, PW Gean - Learning & Memory, 2008 - learnmem.cshlp.org
Endocannabinoids are critically involved in the extinction of fear memory. Here we
examined the effects of repeated cannabinoid administration on the extinction of fear …
examined the effects of repeated cannabinoid administration on the extinction of fear …
WIN 55212-2 impairs contextual fear conditioning through the activation of CB1 cannabinoid receptors
FA Pamplona, RN Takahashi - Neuroscience letters, 2006 - Elsevier
The memory deficits induced by cannabinoid agonists have been found in several
behavioral paradigms. Nevertheless, there is evidence that not all types of memory are …
behavioral paradigms. Nevertheless, there is evidence that not all types of memory are …
Dorsal hippocampus cannabinoid type 1 receptors modulate the expression of contextual fear conditioning in rats: Involvement of local glutamatergic/nitrergic and …
GBL Spiacci, LS Antero, DG Reis, SF Lisboa… - European …, 2016 - Elsevier
The cannabinoid receptor type 1 (CB1) is highly expressed in the dorsal portion of
hippocampus–a brain region that has been involved in the control of conditioned emotional …
hippocampus–a brain region that has been involved in the control of conditioned emotional …
Distinct roles of neuronal and microglial CB2 cannabinoid receptors in the mouse hippocampus
Y Li, J Kim - Neuroscience, 2017 - Elsevier
The effects of cannabinoids are primarily mediated by type-1 cannabinoid receptors in the
brain and type-2 cannabinoid receptors (CB2Rs) in the peripheral immune system …
brain and type-2 cannabinoid receptors (CB2Rs) in the peripheral immune system …