ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
R de Reuver, S Verdonck, E Dierick, J Nemegeer… - Nature, 2022 - nature.com
The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …
ADAR1 mutation causes ZBP1-dependent immunopathology
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …
[HTML][HTML] Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1
M Maurano, JM Snyder, C Connelly, J Henao-Mejia… - Immunity, 2021 - cell.com
The RNA deaminase ADAR1 is an essential negative regulator of the RNA sensor MDA5,
and loss of ADAR1 function triggers inappropriate activation of MDA5 by self-RNAs …
and loss of ADAR1 function triggers inappropriate activation of MDA5 by self-RNAs …
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
GI Rice, PR Kasher, GMA Forte, NM Mannion… - Nature …, 2012 - nature.com
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of
adenosine to inosine in double-stranded RNA (dsRNA) and thereby potentially alter the …
adenosine to inosine in double-stranded RNA (dsRNA) and thereby potentially alter the …
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA
NM Mannion, SM Greenwood, R Young, S Cox… - Cell reports, 2014 - cell.com
The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs.
Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi …
Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi …
ADAR RNA editing in human disease; more to it than meets the I
We review the structures and functions of ADARs and their involvements in human diseases.
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …
ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
R de Reuver, E Dierick, B Wiernicki, K Staes, L Seys… - Cell reports, 2021 - cell.com
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …
ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation
Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …
ADAR1 averts fatal type I interferon induction by ZBP1
H Jiao, L Wachsmuth, S Wolf, J Lohmann, M Nagata… - Nature, 2022 - nature.com
Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases
associated with chronic activation of type I interferon (IFN) responses, including Aicardi …
associated with chronic activation of type I interferon (IFN) responses, including Aicardi …
Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line
Y Li, S Banerjee, SA Goldstein, B Dong, C Gaughan… - Elife, 2017 - elifesciences.org
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA
reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe …
reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe …