The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications
J Zemva, M Schubert - … (Formerly Current Drug Targets-CNS & …, 2014 - ingentaconnect.com
Recent data suggest that brains of patients with Alzheimer's disease (AD) are insulin and
insulin-like growth factor-1 (IGF-1) resistant. So far, there have been two different …
insulin-like growth factor-1 (IGF-1) resistant. So far, there have been two different …
Potential roles of insulin and IGF-1 in Alzheimer's disease
L Gasparini, H Xu - Trends in neurosciences, 2003 - cell.com
Aging is characterized by a significant decline of metabolic and hormonal functions, which
often facilitates the onset of severe age-associated pathologies. One outstanding example of …
often facilitates the onset of severe age-associated pathologies. One outstanding example of …
Brain insulin resistance and the therapeutic value of insulin and insulin-sensitizing drugs in Alzheimer's disease neuropathology
JJ Yang - Acta Neurologica Belgica, 2022 - Springer
The incidence of Alzheimer's disease (AD) is significantly higher in people with diabetes.
Insulin and insulin receptor (IR) signaling intermediates are expressed in the brain. Insulin …
Insulin and insulin receptor (IR) signaling intermediates are expressed in the brain. Insulin …
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital
growth, survival and metabolic functions in the brain. Here we describe specific and …
growth, survival and metabolic functions in the brain. Here we describe specific and …
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease
SM de la Monte, JR Wands - Journal of Alzheimer's Disease, 2005 - content.iospress.com
Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …
vascular dementia is growing exponentially. This review details what is currently known …
Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model …
T Ochiai, T Sano, T Nagayama, N Kubota… - Neurobiology of …, 2021 - Elsevier
Insulin signaling has been implicated in the metabolism as well as aging and longevity.
Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated …
Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated …
The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease
S Freude, K Schilbach… - Current Alzheimer …, 2009 - ingentaconnect.com
In different clinical studies, an association of type 2 diabetes and Alzheimer's disease (AD)
has been described. However, the underlying mechanisms are still unclear. One …
has been described. However, the underlying mechanisms are still unclear. One …
Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease
SM de la Monte - Drugs, 2012 - Springer
Alzheimer's disease (AD) is the most common cause of dementia in North America. Growing
evidence supports the concept that AD is fundamentally a metabolic disease that results in …
evidence supports the concept that AD is fundamentally a metabolic disease that results in …
[HTML][HTML] The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease
B Kim, SE Elzinga, RE Henn, LM McGinley… - Neurobiology of …, 2019 - Elsevier
Alzheimer's disease (AD) is a growing problem worldwide, and there are currently no
effective treatments for this devastating disease. The neurotrophic growth factors insulin and …
effective treatments for this devastating disease. The neurotrophic growth factors insulin and …
Targeting insulin-like growth factor-1 to treat Alzheimer's disease
I Torres-Aleman - Expert opinion on therapeutic targets, 2007 - Taylor & Francis
The 'amyloid cascade hypothesis' proposes that disturbances in amyloid metabolism cause
Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms …
Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms …