The low regenerative capacity of the hair cells of the mammalian inner ear is a major
obstacle for functional recovery following sensorineural hearing loss. A potential treatment is …

Spiral ganglion neurons (SGNs), the primary afferent neurons of the cochlea, degenerate
following a sensorineural hearing loss (SNHL) due to lack of trophic support normally …

Damage and loss of hair cells in the inner ear is the most frequent cause of hearing loss and
balance disorders. Mammalian hair cells do not regenerate in the conventional ways. To …

Application of ouabain to the round window membrane of the gerbil selectively induces the
death of most spiral ganglion neurons and thus provides an excellent model for investigating …

Hair cells in the mature cochlea cannot spontaneously regenerate. One potential approach
for restoring hair cells is stem cell therapy. However, when cells are transplanted into scala …

This study investigated surgical procedures for cell transplantation into the mouse inner ear.
Female C57BL/6 mice were used as recipient animals. Fetal mouse neural stem cells …

Loss of inner ear hair cells leads to incurable balance and hearing disorders because these
sensory cells do not effectively regenerate in humans. A potential starting point for therapy …

Stem cells in various mammalian organs retain the capacity to renew themselves and may
be able to restore damaged tissue. Their existence has been proven by genetic tracer …

Loss of sensory hair cells in the inner ear is a major cause of permanent hearing loss, since
regeneration of hair cells rarely occurs in mammals. The aim of this study was to examine …

Mammalian cochlear sensory epithelial cells are believed to possess minimal regenerative
potential because they halt proliferation during late stage of embryogenesis and never …