Background: Transport proteins, for example the drug export pump P-glycoprotein, are
important for the absorption, distribution and excretion of drugs. Inhibition and induction of P …

1. The molecular and functional characterization of transport proteins is emerging rapidly
and significant numbers of drugs have been shown to be substrates or inhibitors. The …

Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …

Drug transporters are increasingly recognized as a key determinant of drug disposition.
Recent studies have revealed that targeted expression of drug uptake and efflux …

Traditionally, drug-induced changes in cytochrome P450 isoenzyme activity, causing
changes in drug metabolism and bioavailability, have been the main focus of drug …

Members of the organic anion transporting polypeptide (OATP) family are responsible for the
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …

▪ Abstract Recent studies have revealed the import role played by transporters in the renal
and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate …

The transporter-mediated uptake of drugs from blood into hepatocytes is a prerequisite for
intrahepatic drug action or intracellular drug metabolism before excretion. Therefore, uptake …

Uptake transporters in the basolateral membrane of hepatocytes are important for the
hepatobiliary elimination of drugs. Further, since drug-metabolizing enzymes are located …

Introduction: Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small
intestine, liver, brain and other organs play important roles in absorption, excretion and …