Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion …
Y Nozaki, S Izumi - Drug Metabolism and Pharmacokinetics, 2020 - Elsevier
Hepatic uptake mediated by organic anion transporting polypeptide (OATP) 1B1 and 1B3
can serve as a major elimination pathway for various anionic drugs and as a site of drug …
can serve as a major elimination pathway for various anionic drugs and as a site of drug …
Effect of human plasma on hepatic uptake of organic anion–transporting polypeptide 1B substrates: studies using transfected cells and primary human hepatocytes
Y Bi, S Ryu, DA Tess, AD Rodrigues… - Drug Metabolism and …, 2021 - ASPET
Current challenges with the in vitro–in vivo extrapolation (IVIVE) of hepatic uptake clearance
involving organic anion–transporting polypeptide (OATP) 1B1/1B3 hinder drug design …
involving organic anion–transporting polypeptide (OATP) 1B1/1B3 hinder drug design …
Meta-analysis of expression of hepatic organic anion–transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue
J Badée, B Achour, A Rostami-Hodjegan… - Drug Metabolism and …, 2015 - ASPET
Organic anion–transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 transporters
play an important role in hepatic drug disposition. Recently, an increasing number of studies …
play an important role in hepatic drug disposition. Recently, an increasing number of studies …
Liver-selective distribution in rats supports the importance of active uptake into the liver via organic anion transporting polypeptides (OATPs) in humans
T Mikkaichi, D Nakai, Y Yoshigae, T Imaoka… - Drug Metabolism and …, 2015 - Elsevier
Organic anion transporting polypeptide (OATP) 1B1 and 1B3 are key molecules that are
involved in hepatic uptake related to drug elimination, and OATP-mediated drug interactions …
involved in hepatic uptake related to drug elimination, and OATP-mediated drug interactions …
Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond
Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …
the absorption, distribution and elimination processes of drugs. The organic anion …
Relative activity factor (RAF)-based scaling of uptake clearance mediated by organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 in human hepatocytes
S Izumi, Y Nozaki, H Kusuhara, K Hotta… - Molecular …, 2018 - ACS Publications
In vitro–in vivo extrapolation based on uptake clearance determined in human hepatocytes
has been used to predict in vivo hepatic clearance of organic anion transporting polypeptide …
has been used to predict in vivo hepatic clearance of organic anion transporting polypeptide …
Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption
Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …
and are increasingly being recognized as important factors in governing drug and …
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 as important regulators of the pharmacokinetics of substrate drugs
K Maeda - Biological and Pharmaceutical Bulletin, 2015 - jstage.jst.go.jp
Nobody doubts the importance of organic anion transporting polypeptide (OATP) 1B1 and
1B3 in the clinical pharmacokinetics of substrate drugs. Based on the theory of …
1B3 in the clinical pharmacokinetics of substrate drugs. Based on the theory of …
Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions
The risk assessment of organic anion transporting polypeptide (OATP) 1B1–mediated drug-
drug interactions (DDIs) is an indispensable part of drug development. We previously …
drug interactions (DDIs) is an indispensable part of drug development. We previously …
Mechanistic account of distinct change in organic anion transporting polypeptide 1B (OATP1B) substrate pharmacokinetics during OATP1B-mediated drug-drug …
PV Hegde, BL Morse - Drug Metabolism and Disposition, 2024 - ASPET
The role of transporters in drug clearance is widely acknowledged, directly and indirectly by
facilitating tissue/enzyme exposure. Through the latter, transporters also affect volume of …
facilitating tissue/enzyme exposure. Through the latter, transporters also affect volume of …
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