Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions
A Koenen, HK Kroemer, M Grube… - Expert review of …, 2011 - Taylor & Francis
At present, many patients are medicated with various drugs, which are, at the same time,
associated with an increased risk of drug–drug interactions (DDIs). Detailed analysis of …
associated with an increased risk of drug–drug interactions (DDIs). Detailed analysis of …
Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance
SPF Tan, A Tillmann, SJ Murby… - Molecular …, 2024 - ACS Publications
Modulation of the transport-mediated active uptake by human serum albumin (HSA) for
highly protein-bound substrates has been reported and improved the in vitro-to-in vivo …
highly protein-bound substrates has been reported and improved the in vitro-to-in vivo …
Improving the translation of organic anion transporting polypeptide substrates using HEK293 cell data in the presence and absence of human plasma via …
CM Bowman, B Chen, J Cheong, L Liu, Y Chen… - Drug Metabolism and …, 2021 - ASPET
Accurately predicting the pharmacokinetics of compounds that are transporter substrates
has been notoriously challenging using traditional in vitro systems and physiologically …
has been notoriously challenging using traditional in vitro systems and physiologically …
Impact of genetic variation in OATP transporters to drug disposition and response
IY Gong, RB Kim - Drug metabolism and pharmacokinetics, 2013 - jstage.jst.go.jp
There has been remarkable progress during the past decade in understanding of how
genetic variations in drug metabolizing enzymes and transporters contribute to observed …
genetic variations in drug metabolizing enzymes and transporters contribute to observed …
Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1
The organic anion transporting polypeptides OATPs are key membrane transporters for
which crystal structures are not currently available. They transport a diverse array of …
which crystal structures are not currently available. They transport a diverse array of …
Transporter‐enzyme interplay: deconvoluting effects of hepatic transporters and enzymes on drug disposition using static and dynamic mechanistic models
MV Varma, AF El‐Kattan - The Journal of Clinical …, 2016 - Wiley Online Library
A large body of evidence suggests hepatic uptake transporters, organic anion‐transporting
polypeptides (OATPs), are of high clinical relevance in determining the pharmacokinetics of …
polypeptides (OATPs), are of high clinical relevance in determining the pharmacokinetics of …
Disposition pathway-dependent approach for predicting organic anion-transporting polypeptide-mediated drug–drug interactions
ZY Hu - Clinical pharmacokinetics, 2013 - Springer
Abstract Background and Objective Organic anion-transporting polypeptide (OATP)-
mediated drug–drug interactions (DDIs) are among the most important classes of clinically …
mediated drug–drug interactions (DDIs) are among the most important classes of clinically …
Investigation of fluorescein derivatives as substrates of organic anion transporting polypeptide (OATP) 1B1 to develop sensitive fluorescence-based OATP1B1 …
S Izumi, Y Nozaki, T Komori, O Takenaka… - Molecular …, 2016 - ACS Publications
Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic
uptake of various drugs. Because OATP1B1 is a site of drug–drug interactions (DDIs) …
uptake of various drugs. Because OATP1B1 is a site of drug–drug interactions (DDIs) …
Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin …
Z Yan, L Ma, N Hwang, J Huang, JR Kenny… - Drug Metabolism and …, 2024 - ASPET
Extrapolating in vivo hepatic clearance from in vitro uptake data is a known challenge,
especially for organic anion-transporting polypeptide transporter (OATP) substrates, and the …
especially for organic anion-transporting polypeptide transporter (OATP) substrates, and the …
New strategies to address drug-drug interactions involving OATPs.
A Poirier, C Funk, T Lave, J Noe - Current opinion in drug discovery …, 2007 - europepmc.org
Pharmacokinetic drug-drug interactions (DDIs) are a major concern in drug development.
Drug transport, along with drug metabolism via cytochrome P450s (CYPs), is increasingly …
Drug transport, along with drug metabolism via cytochrome P450s (CYPs), is increasingly …