A key feature of inflammatory bowel disease (IBD) is disruption of the intestinal epithelial
barrier by unknown mechanisms. Integrity of the epithelial barrier is determined by an apical …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the underlying interstitium. This intestinal barrier is primarily regulated by the apical …

Changes of the intestinal mucosal barrier are considered to play a role in the pathogenesis
of inflammatory bowel disease (IBD). Our experiments were designed to identify …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic …

The single-cell thick intestinal epithelial cell (IEC) lining with its protective layer of mucus is
the primary barrier protecting the organism from the harsh environment of the intestinal …

The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …

The epithelium in inflamed intestinal segments of patients with Crohn's disease is
characterized by a reduction of tight junction strands, strand breaks, and alterations of tight …

The epithelial monolayer of the intestine is a selective barrier permitting nutrient and
electrolyte absorption yet acting to protect the underlying tissue compartments and cellular …

Abstract Background and Aim: Epithelial barrier function is impaired in ulcerative colitis
(UC), but the pathophysiological mechanisms leading to this barrier defect are still far from …

Although the critical factors necessary for IBD pathogenesis remain mysterious, interest in
the potential role of defective epithelial barrier function continues to grow. New insight into …