Introduction The intestinal barrier is a multi-faced structure lining the surface of the intestinal
mucosa of the GI tract. To exert its main functions as a physical and immunological defense …

Barrier dysfunction in inflammatory bowel disease contributes to diarrhea by a leak flux
mechanism and can cause mucosal inflammation secondary to luminal antigen uptake …

A critical function of the epithelial lining is to form a barrier that separates luminal contents
from the underlying interstitium. This barrier function is primarily regulated by the apical …

The epithelial apical junctional complex is important in determining epithelial barrier
properties. Recent studies have highlighted contribution of proinflammatory cytokines and …

Eukaryotic cells take up macromolecules and particles from the surrounding milieu and also
internalize membrane proteins via a precise process of endocytosis. The role of endocytosis …

The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

Intestinal barrier dysfunction is a main feature of the inflammatory bowel diseases (IBD),
Crohn's disease and ulcerative colitis. Leak flux diarrhoea and a facilitated uptake of …

The intestinal epithelium forms a key protective barrier that separates internal organs from
the harmful environment of the gut lumen. Increased permeability of the gut barrier is a …

Intestinal epithelial barrier defects, or increased paracellular permeability, were first reported
in patients with Crohn's disease (CD) over 25 years ago. Although increased permeability …

In inflammatory bowel disease (IBD), epithelial barrier function is impaired contributing to
diarrhea by a leak flux mechanism and perpetuating inflammation by an increased luminal …