The intestinal epithelium restricts free passage of toxic and infectious molecules from the gut
lumen while allowing selective paracellular absorption across the tight junction …

Abstract Background and Aims Studies have shown a decrease in key tight junction (TJ)
proteins such as ZO-1 and occludin in both inflammatory bowel disease (IBD) and …

Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are complex, multifactorial disorders that lead to chronic and relapsing intestinal …

Research efforts in inflammatory bowel disease (IBD) have been directed towards the
epithelium as it has become clear that epithelial cells play a critical role in inflammatory …

We intended to see the pattern of TJ protein expression along with ultrastructural changes in
colonic biopsies from patients with Crohn's disease (CD), ulcerative colitis (UC), and …

Background The mechanisms underlying loss of intestinal epithelial barrier [IEB] function in
Crohn's disease [CD] are poorly understood. We tested whether human enteroids generated …

The colonic mucosa provides a vital defensive barrier separating the body from the microbial
populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Although epithelial cells are continuously shed from the surface of the intestine, the intestinal
epithelium maintains the integrity of the epithelial barrier. This is achieved through a highly …

Background: Epithelial barrier function is impaired in Crohn's disease. Aim: To define the
underlying cellular mechanisms with special attention to tight junctions. Methods: Biopsy …