Background Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely
determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied …

Purpose: Docetaxel pharmacokinetic (PK) parameters, notably clearance and exposure
(AUC), are characterized by large interindividual variability. The purpose of this study was to …

Background Area under time-concentration curve (AUC) of docetaxel is related with its
toxicity and efficacy. The aim of this study is to investigate the target range of docetaxel AUC …

Docetaxel is a frequently used chemotherapeutic agent in the treatment of solid cancers.
Because of the large inter-individual variability (IIV) in the pharmacokinetics (PK) of …

Purpose Docetaxel is a cytotoxic drug used for first-line treatment of various malignancies. It
has a narrow therapeutic index and shows wide interpatient variability in clearance and …

Docetaxel (Taxotere®) has been one of the most important chemotherapeutic drugs for
cancer treatment since 1996. Although a large number of clinical studies have been …

Purpose The aim of this study was to compare CKD-810 (test docetaxel) with
Taxotere®(reference docetaxel) in terms of pharmacokinetics and safety for patients with …

The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the
nanoparticle‐bound nab‐paclitaxel are among the most widely used anticancer drugs. Still …

Purpose Docetaxel is metabolized by cytochrome P450 (CYP3A4) enzyme, and the area
under the concentration-time curve (AUC) is correlated with neutropenia. We developed a …

e13539 Background: RAM is a human IgG1 monoclonal antibody that specifically targets the
extracellular domain of vascular endothelial growth factor receptor-2. The primary objective …