Causal role of lipid metabolome on the risk of ischemic stroke, its etiological subtypes, and long-term outcome: A Mendelian randomization study

JM Martín-Campos, J Cárcel-Márquez, L Llucià-Carol… - Atherosclerosis, 2023 - Elsevier
Background and aims The lipid profile is consistently associated with coronary artery
disease (CAD) and ischemic stroke (IS). However, the lipoprotein subfractions have not …

[HTML][HTML] Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults

MA Ward, BB Bendlin, DG McLaren… - Frontiers in aging …, 2010 - frontiersin.org
Dyslipidemia is common in adults and contributes to high rates of cardiovascular disease
and may be linked to subsequent neurodegenerative and neurovascular diseases. This …

[HTML][HTML] Non-fasting high-density lipoprotein is associated with white matter microstructure in healthy older adults

NF Johnson, BT Gold, D Ross, AL Bailey… - Frontiers in Aging …, 2019 - frontiersin.org
A growing body of evidence indicates that biomarkers of cardiovascular risk may be related
to cerebral health. However, little is known about the role that non-fasting lipoproteins play in …

Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

S Xu, S Wen, Y Yang, J He, H Yang, Y Qu, Y Zeng… - Neurology, 2024 - neurology.org
Background and Objectives Accumulating evidence connects diverse components of body
composition (eg, fat, muscle, and bone) to neurodegenerative disease risk, yet their interplay …

[HTML][HTML] Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease

M Sala, A de Roos, GJ Blauw, HAM Middelkoop… - BMC neurology, 2015 - Springer
Background The purpose of this study is to investigate whether changes in brain
microstructure, detected by magnetization transfer imaging, are associated with cognition in …

[HTML][HTML] Obesity and brain volumes: mediation by cardiometabolic and inflammatory measures

Q Zhou, W Zhu, X Cai, J Jing, M Wang… - Stroke and Vascular …, 2024 - svn.bmj.com
Background This study aimed to investigate the relationship between overall obesity, central
obesity and brain volumes, as well as to determine the extent to which cardiometabolic and …

Causal associations between blood lipids and brain structures: a Mendelian randomization study

Y Zeng, R Guo, S Cao, H Yang - Cerebral Cortex, 2023 - academic.oup.com
The potential causal association between dyslipidemia and brain structures remains
unclear. Therefore, this study aimed to investigate whether circulating lipids are causally …

Lipid metabolism, abdominal adiposity, and cerebral health in the Amish

M Ryan, P Kochunov, LM Rowland, BD Mitchell… - …, 2017 - Wiley Online Library
Objective To assess the association between peripheral lipid/fat profiles and cerebral gray
matter (GM) and white matter (WM) in healthy Old Order Amish (OOA). Methods Blood lipids …

Metabolically healthy obesity and lipids may be protective factors for pathological changes of Alzheimer's disease in cognitively normal adults

SJ Huang, YH Ma, YL Bi, XN Shen… - Journal of …, 2021 - Wiley Online Library
The associations between obesity and Alzheimer's disease (AD) at different ages have been
debated. Recent evidence implied the protective effects of metabolically healthy obesity on …

Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness

SE Kim, JS Lee, S Woo, S Kim, HJ Kim, S Park, BI Lee… - Neurology, 2019 - AAN Enterprises
Objective To investigate whether cardiometabolic factors were associated with age-related
differences in cortical thickness in relation to sex. Methods In this cross-sectional study, we …