Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study

C Shen, C Liu, A Qiu - Translational Psychiatry, 2023 - nature.com
Abstracts Metabolic syndrome (MetS) is characterized by a constellation of metabolic risk
factors, including obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) levels …

Better brain connectivity is associated with higher total fat mass and lower visceral adipose tissue in military pilots

D Cárdenas, I Madinabeitia, J Vera, C de Teresa… - Scientific Reports, 2020 - nature.com
A lack of exercise leads to being overweight or obese affecting regional brain structure and
functional connectivity associated with impaired cognitive function and dementia. In recent …

Association between carotid atheroma and cerebral cortex structure at age 73 years

S Alhusaini, S Karama, TV Nguyen, A Thiel… - Annals of …, 2018 - Wiley Online Library
Objective To examine the relationship between carotid atherosclerosis and cerebral cortical
thickness and investigate whether cortical thickness mediates the association between …

Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank

L Feng, Z Ye, C Mo, J Wang, S Liu, S Gao… - Journal of …, 2023 - journals.lww.com
Background: Elevated blood pressure (BP) is a modifiable risk factor associated with
cognitive impairment and cerebrovascular diseases. However, the causal effect of BP on …

Increase in right temporal cortex thickness is related to decline of overall cognitive function in patients with hypertension

W Li, L Yue, S Xiao - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Background: Hypertension is associated with poorer cognitive functions, but the
mechanisms are unclear. Objective: This research aims to explore the cognitive status of …

Impact of lifestyle dimensions on brain pathology and cognition

S Schreiber, J Vogel, HD Schwimmer, SM Marks… - Neurobiology of …, 2016 - Elsevier
Single lifestyle factors affect brain biomarkers and cognition. Here, we addressed the
covariance of various lifestyle elements and investigated their impact on positron emission …

Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank

CP Pflanz, DJ Tozer, EL Harshfield, J Tay… - International Journal of …, 2022 - nature.com
Background Obesity is a risk factor for both cardiovascular disease and dementia, but the
mechanisms underlying this association are not fully understood. We examined associations …

Associations between vascular risk factors and brain MRI indices in UK Biobank

SR Cox, DM Lyall, SJ Ritchie, ME Bastin… - European heart …, 2019 - academic.oup.com
Aims Several factors are known to increase risk for cerebrovascular disease and dementia,
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …

Abdominal obesity and brain atrophy in type 2 diabetes mellitus

RED Climie, C Moran, M Callisaya, L Blizzard… - PloS one, 2015 - journals.plos.org
Aim Type 2 diabetes mellitus (T2D) is associated with gray matter atrophy. Adiposity and
physical inactivity are risk factors for T2D and brain atrophy. We studied whether the …

Sex Differences in the Association of Age at Hypertension Diagnosis With Brain Structure

A Kaur, A Angarita Fonseca, R Lissaman… - …, 2024 - Am Heart Assoc
BACKGROUND: Sex differences exist in the likelihood of cognitive decline. The age at
hypertension diagnosis is a unique contributor to brain structural changes associated with …