Background and Objectives Cerebral small vessel disease is a major cause of stroke and
dementia. Metabolomics can help identify novel risk factors to better understand …

Objective—Pathologies in the heart–brain axis might, independently or in combination,
accelerate the process of brain parenchymal loss. We aimed to investigate the association of …

Background Serum lipids [total cholesterol (TC), low density lipoprotein cholesterol (LDL-C),
high density lipoprotein cholesterol (HDL-C) and triglyceride (TG)] are risk factors for stroke …

Elevated vascular disease risk associates with poorer cognitive function, but the mechanism
for this link is poorly understood. A leading theory, the structural-functional model argues …

Background and Purpose—The purpose of this study was to investigate whether the
Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are …

Maternal obesity is associated with increased risk of diabetes, cardiovascular disease and
hypertension in adult offspring. Midlife hypercholesterolemia and hypertension are risk …

Background: While obesity is linked with brain atrophy and dementia incidence,
associations with regional adiposity are uncertain. Our goal was to determine whether …

Background: The aging population and high rates of Alzheimer's disease (AD) create
significant medical burdens, prompting a need for early prevention. Targeting modifiable risk …

There is a recognized link between risk factors for non-communicable diseases and brain
health. However, the specific effects that they have on brain health are still poorly …

The increasing prevalence of Metabolic Syndrome (MetS), defined as the clustering of
abdominal obesity, dyslipidemia, hypertension, and hyperglycemia, appears to be driving …