Ischemic heart disease and vascular risk factors are associated with accelerated brain aging

E Rauseo, A Salih, Z Raisi-Estabragh, N Aung… - Cardiovascular …, 2023 - jacc.org
Background Ischemic heart disease (IHD) has been linked with poor brain outcomes. The
brain magnetic resonance imaging–derived difference between predicted brain age and …

Systemic inflammation as a predictor of brain aging: contributions of physical activity, metabolic risk, and genetic risk

F Corlier, G Hafzalla, J Faskowitz, LH Kuller, JT Becker… - Neuroimage, 2018 - Elsevier
Inflammatory processes may contribute to risk for Alzheimer's disease (AD) and age-related
brain degeneration. Metabolic and genetic risk factors, and physical activity may, in turn …

A systematic review of the Impact of Type 2 Diabetes on Brain Cortical Thickness

M Motaghi, O Potvin, S Duchesne - Frontiers in Dementia - frontiersin.org
Type 2 diabetes (T2D) has been linked to cognitive impairment and dementia, but its impact
on brain cortical structures in individuals prior to or without cognitive impairment remains …

Visceral adipose tissue is associated with microstructural brain tissue damage

RL Widya, LJM Kroft, I Altmann‐Schneider… - …, 2015 - Wiley Online Library
Objective Obesity has been associated with microstructural brain tissue damage. Different
fat compartments demonstrate different metabolic and endocrine behaviors. The aim was to …

Common brain structural alterations associated with cardiovascular disease risk factors and Alzheimer's dementia: Future directions and implications

M Lamar, EA Boots, K Arfanakis, LL Barnes… - Neuropsychology …, 2020 - Springer
Recent reports suggest declines in the age-specific risk of Alzheimer's dementia in higher
income Western countries. At the same time, investigators believe that worldwide trends of …

Central obesity and the aging brain

W Jagust, D Harvey, D Mungas, M Haan - Archives of neurology, 2005 - jamanetwork.com
Background Central adiposity as an indicator of visceral fat is linked to vascular and
metabolic factors that in turn are related to cognitive decline and dementia. Objective To …

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

A Kapasi, AW Capuano, M Lamar… - Journal of the …, 2024 - Am Heart Assoc
Background Lower hippocampal volume is associated with late‐life cognitive decline and is
an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular …

[HTML][HTML] Adipose tissue and brain metabolic responses to western diet—is there a similarity between the two?

A Mazzoli, MS Spagnuolo, C Gatto, M Nazzaro… - International Journal of …, 2020 - mdpi.com
Dietary fats and sugars were identified as risk factors for overweight and neurodegeneration,
especially in middle-age, an earlier stage of the aging process. Therefore, our aim was to …

Triglycerides are negatively correlated with cognitive function in nondemented aging adults.

V Parthasarathy, DT Frazier, BM Bettcher… - …, 2017 - psycnet.apa.org
Objective: Vascular risk factors like hyperlipidemia may adversely affect brain function. We
hypothesized that increased serum triglycerides are associated with decreased executive …

Association of red blood cell omega-3 fatty acids with MRI markers and cognitive function in midlife: the framingham heart study

CL Satizabal, JJ Himali, AS Beiser, V Ramachandran… - Neurology, 2022 - AAN Enterprises
Background and Objectives Diet may be a key contributor to brain health in midlife. In
particular, omega-3 fatty acids have been related to better neurologic outcomes in older …