A Castiglioni, G Corna, E Rigamonti, V Basso… - PloS one, 2015 - journals.plos.org
Muscle injury induces a classical inflammatory response in which cells of the innate immune system rapidly invade the tissue. Macrophages are prominently involved in this response …
J Cho, W Kuswanto, C Benoist… - Proceedings of the …, 2019 - National Acad Sciences
Foxp3+ CD4+ regulatory T cells (Tregs) play important roles in controlling both homeostatic processes and immune responses at the tissue and organismal levels. For example, Tregs …
J Wu, B Ren, D Wang, H Lin - Cell Death & Disease, 2022 - nature.com
Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the …
SA Villalta, W Rosenthal, L Martinez, A Kaur… - Science translational …, 2014 - science.org
We examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and inflammation in the mdx mouse model of Duchenne muscular dystrophy (DMD). Although …
Skeletal muscle regeneration results from the activation and differentiation of myogenic stem cells, called satellite cells, located beneath the basal lamina of the muscle fibers …
M Panduro, C Benoist, D Mathis - Proceedings of the …, 2018 - National Acad Sciences
Skeletal muscle regeneration is a highly orchestrated process that depends on multiple immune-system cell types, notably macrophages (MFs) and Foxp3+ CD4+ regulatory T …
The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy …
W Kuswanto, D Burzyn, M Panduro, KK Wang, YC Jang… - Immunity, 2016 - cell.com
Normal repair of skeletal muscle requires local expansion of a special population of Foxp3+ CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of …
Muscle-residing regulatory T cells (Tregs) control local tissue integrity and function. However, the molecular interface connecting Treg-based regulation with muscle function …