Pulmonary fibrosis (PF) is the pathological change of end-stage interstitial lung diseases
with high mortality and limited therapeutic options. Lung macrophages have distinct subsets …

In this study, we leveraged a combination of single cell RNAseq, cytometry by time of flight
(CyTOF), and flow cytometry to study the biology of a unique macrophage population in …

Idiopathic pulmonary fibrosis (IPF) is the representative phenotype of interstitial lung disease
where severe scarring develops in the lung interstitium. Although antifibrotic treatments are …

Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …

We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …

Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the
etiology remains poorly understood. This disease can be lethal and currently has no specific …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …