Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after …
K Obata, H Yamanaka, Y Dai, T Tachibana… - Journal of …, 2003 - Soc Neuroscience
To investigate the intracellular signal transduction pathways involved in regulating the gene
expression of brain-derived neurotrophic factor (BDNF) in primary afferent neurons, we …
expression of brain-derived neurotrophic factor (BDNF) in primary afferent neurons, we …
Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation
HJ Cho, SY Kim, MJ Park, DS Kim, JK Kim, MY Chu - Brain research, 1997 - Elsevier
It is well known that the nerve growth factor (NGF) may serve as a link between inflammation
and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically …
and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically …
Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
K Obata, H Yamanaka, Y Dai, T Mizushima, T Fukuoka… - Neuroscience, 2004 - Elsevier
Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain …
PC Duarte, B St-Jacques, W Ma - Experimental neurology, 2012 - Elsevier
Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat
dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain …
dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain …
Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation
Our recent study showed that peripheral inflammation induced an increased expression of
brain-derived neurotrophic factor (BDNF) mRNA which was mediated by nerve growth factor …
brain-derived neurotrophic factor (BDNF) mRNA which was mediated by nerve growth factor …
Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model
T Fukuoka, E Kondo, Y Dai, N Hashimoto… - Journal of …, 2001 - Soc Neuroscience
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two major
members of the neurotrophin family. Using immunohistochemistry and in situ hybridization …
members of the neurotrophin family. Using immunohistochemistry and in situ hybridization …
Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: implications in the development of neuropathic pain
H Uchida, Y Matsushita, H Ueda - Neuroscience, 2013 - Elsevier
Brain-derived neurotrophic factor (BDNF) is known to be up-regulated in the dorsal root
ganglion (DRG) after peripheral nerve injury, and to contribute to neuropathic pain. Here, we …
ganglion (DRG) after peripheral nerve injury, and to contribute to neuropathic pain. Here, we …
Expression of brain-derived neurotrophic factor in rat dorsal root ganglia, spinal cord and gracile nuclei in experimental models of neuropathic pain
SO Ha, JK Kim, HS Hong, DS Kim, HJ Cho - Neuroscience, 2001 - Elsevier
Chronic constriction injury of the sciatic nerve and lumbar L5 and L6 spinal nerve ligation
provide animal models for pain syndromes accompanying peripheral nerve injury and …
provide animal models for pain syndromes accompanying peripheral nerve injury and …
Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat
LJ Zhou, T Yang, X Wei, Y Liu, WJ Xin, Y Chen… - Brain, behavior, and …, 2011 - Elsevier
It has been shown that following peripheral nerve injury brain-derived neurotrophic factor
(BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF …
(BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF …
The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior
K Obata, H Yamanaka, K Kobayashi, Y Dai… - Neuroscience, 2006 - Elsevier
A number of rat neuropathy models have been developed to simulate human neuropathic
pain conditions, such as spontaneous pain, hyperalgesia, and allodynia. In the present …
pain conditions, such as spontaneous pain, hyperalgesia, and allodynia. In the present …
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