Antibodies have the capability of binding a wide range of antigens due to the diversity of the
six loops constituting the complementarity determining region (CDR). Among the six loops …

Predicting the conformations of loops is a critical aspect of protein comparative (homology)
modeling. Despite considerable advances in developing loop prediction algorithms, refining …

We present the blinded prediction results in the Second Antibody Modeling Assessment
(AMA‐II) using a fully automatic antibody structure prediction method implemented in the …

Antibodies are proteins of the immune system that are able to bind to a huge variety of
different substances, making them attractive candidates for therapeutic applications …

Residue-level potentials of mean force were widely used for protein backbone refinements
to avoid simultaneous sampling of side-chain conformations. The interaction energy …

So far the difficulty to predict the structure of the third hypervariable loop of the heavy chain
of antibodies has represented the main limitation in modelling the complete antigen binding …

A blinded study to assess the state of the art in three‐dimensional structure modeling of the
variable region (Fv) of antibodies was conducted. Nine unpublished high‐resolution x‐ray …

The antigen-binding site of antibodies, also known as complementarity-determining region
(CDR), has hypervariable sequence properties. In particular, the third CDR loop of the heavy …

The success of antibody‐based drugs has led to an increased demand for predictive
computational tools to assist antibody engineering efforts surrounding the six hypervariable …

Antibodies are used extensively in medical and biological research. Their complementarity
determining regions (CDRs) define the majority of their antigen binding functionality. CDR …