Rational use of tocilizumab in the treatment of novel coronavirus pneumonia

S Zhang, L Li, A Shen, Y Chen, Z Qi - Clinical drug investigation, 2020 - Springer
Since December 2019, a novel coronavirus pneumonia (COVID-19) has broken out in
Wuhan, China and spread rapidly. Recent studies have found that⁓ 15.7% of patients …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …

A comprehensive review of tocilizumab in COVID‐19 acute respiratory distress syndrome

S Khiali, E Khani… - The Journal of Clinical …, 2020 - Wiley Online Library
Currently, the world is facing the pandemic of a novel strain of beta‐coronavirus known as
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Acute respiratory distress …

Why tocilizumab could be an effective treatment for severe COVID-19?

B Fu, X Xu, H Wei - Journal of translational medicine, 2020 - Springer
A severe pneumonia-associated respiratory syndrome caused by a new coronavirus was
identified in December 2019 (COVID-19), spread rapidly and has become a world-wide …

Promising effects of tocilizumab in COVID-19: a non-controlled, prospective clinical trial

F Dastan, A Saffaei, S Haseli, M Marjani… - International …, 2020 - Elsevier
Background The clinical presentation of SARS-CoV-2 infection ranges from mild symptoms
to severe complications, including acute respiratory distress syndrome. In this syndrome …

Treatment of severe COVID-19 with tocilizumab mitigates cytokine storm and averts mechanical ventilation during acute respiratory distress: a case report and …

F Farooqi, N Dhawan, R Morgan, J Dinh… - Tropical medicine and …, 2020 - mdpi.com
COVID-19, caused by the novel severe acute respiratory coronavirus 2 (SARS-CoV-2),
emerged in Wuhan, China, in 2019 and has resulted in the current pandemic. The disease …

Tocilizumab for the treatment of adult patients with severe COVID‐19 pneumonia: a single‐center cohort study

M Fernández‐Ruiz, F López‐Medrano… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) can lead to a massive cytokine release. The
use of the anti‐interleukin‐6 receptor monoclonal antibody tocilizumab (TCZ) has been …

Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far?

Y Zhang, Y Zhong, L Pan, J Dong - Drug discoveries & therapeutics, 2020 - jstage.jst.go.jp
The world is in the midst of the coronavirus disease 2019 (COVID-19) pandemic. Interleukin
6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory …

Tocilizumab for treatment patients with COVID-19: recommended medication for novel disease

H Samaee, M Mohsenzadegan, S Ala… - International …, 2020 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) virus has spread all over the world.
Scientists are trying to discover drugs as effective treatment for patients with COVID-19. So …

[HTML][HTML] Tocilizumab for treatment of patients with severe COVID–19: A retrospective cohort study

T Kewan, F Covut, MJ Al–Jaghbeer, L Rose… - …, 2020 - thelancet.com
Background Tocilizumab was approved for chimeric antigen receptor T–cell therapy induced
cytokine release syndrome and it may provide clinical benefit for selected COVID–19 …