Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion

E Lipšic, P van der Meer, RH Henning… - Journal of …, 2004 - journals.lww.com
Erythropoietin (EPO) is a hormone known to stimulate hematopoiesis. However, recent
research suggests additional properties of EPO, such as protection against …

[HTML][HTML] Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart

E Gao, M Boucher, JK Chuprun… - American Journal …, 2007 - journals.physiology.org
Recent studies from our lab and others have shown that the hematopoietic cytokine
erythropoietin (EPO) can protect the heart from ischemic damage in a red blood cell …

Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo

AJ Bullard, P Govewalla, DM Yellon - Basic research in cardiology, 2005 - Springer
Objective Erythropoietin (EPO) is a hormone that is currently used to treat patients with renal
failure and anaemia. However, it has also been shown to protect against …

Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia‐reperfusion injury

P van der Meer, E Lipsic, RH Henning… - European Journal of …, 2004 - Wiley Online Library
Background: Recent studies show that erythropoietin (EPO) plays a protective role in brain
ischemia. In this condition, administration of EPO protects neurons from ischemic damage …

Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts

A Hirata, T Minamino, H Asanuma, S Sanada… - … drugs and therapy, 2005 - Springer
Although recent studies suggest that erythropoietin (EPO) may reduce multiple features of
the myocardial ischemia/reperfusion injury, the cellular mechanisms and the clinical …

Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear …

B Xu, G Dong, H Liu, Y Wang, H Wu… - Annals of Clinical & …, 2005 - Assoc Clin Scientists
Erythropoietin (EPO), known for its role in stimulating erythropoiesis, has recently been
shown to have a cardio-protective effect in animal models of myocardial ischemia …

Protective effects of erythropoietin in cardiac ischemia: from bench to bedside

E Lipšic, RG Schoemaker, P van der Meer… - Journal of the American …, 2006 - jacc.org
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates
hematopoiesis in the bone marrow. However, recent studies have also shown important …

Cardioprotection by recombinant human erythropoietin following acute experimental myocardial infarction: dose response and therapeutic window

C Moon, M Krawczyk, D Paik, EG Lakatta… - … drugs and therapy, 2005 - Springer
Background: Recombinant human erythropoietin (rhEPO) protects tissue from ischemic
damage, but translation of this finding into useful guidelines with respect to human trials for …

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

L Calvillo, R Latini, J Kajstura, A Leri… - Proceedings of the …, 2003 - National Acad Sciences
Erythropoietin (EPO), originally identified for its critical hormonal role in promoting
erythrocyte survival and differentiation, is a member of the large and diverse cytokine …

An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection

MA Bogoyevitch - Cardiovascular research, 2004 - academic.oup.com
Erythropoietin (Epo) was once thought to act exclusively in the formation of red blood cells.
As recently reviewed by Smith et al.[Cardiovasc. Res. 59 (2003) 538–548], Epo can also act …