Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

JV Raelson, RD Little, A Ruether… - Proceedings of the …, 2007 - National Acad Sciences
Genome-wide association (GWA) studies offer a powerful unbiased method for the
identification of multiple susceptibility genes for complex diseases. Here we report the …

Genome-wide association studies and Crohn's disease

JC Lee, M Parkes - Briefings in functional genomics, 2011 - academic.oup.com
The development of genome-wide association scanning (GWAS) has revolutionized the
search for genetic loci associated with complex diseases. Crohn's disease (CD), together …

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

A Franke, DPB McGovern, JC Barrett, K Wang… - Nature …, 2010 - nature.com
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study

A Alonso, E Domènech, A Julià, J Panés… - Gastroenterology, 2015 - Elsevier
Background & Aims Crohn's disease is a highly heterogeneous inflammatory bowel disease
comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have …

Genome‐wide association studies in Crohn's disease: past, present and future

B Verstockt, KGC Smith, JC Lee - Clinical & translational …, 2018 - Wiley Online Library
Over the course of the past decade, genome‐wide association studies (GWAS) have
revolutionised our understanding of complex disease genetics. One of the diseases that has …

Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease

K Fransen, MC Visschedijk… - Human molecular …, 2010 - academic.oup.com
Genome-wide association studies (GWAS) for Crohn's disease (CD) have identified loci
explaining∼ 20% of the total genetic risk of CD. Part of the other genetic risk loci is probably …

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

JZ Liu, S Van Sommeren, H Huang, SC Ng, R Alberts… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

JC Barrett, S Hansoul, DL Nicolae, JH Cho, RH Duerr… - Nature …, 2008 - nature.com
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

New links to the pathogenesis of Crohn disease provided by genome-wide association scans

CG Mathew - Nature Reviews Genetics, 2008 - nature.com
Genome-wide association scans (GWAS) using large case–control samples and several
hundred thousand genetic markers have uncovered at least ten new genomic regions …

A genome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population

K Yamazaki, J Umeno, A Takahashi, A Hirano… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Crohn's disease is an inflammatory bowel disease induced by
multiple genetic and environmental factors. Genome-wide association studies have …