Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-
independently, provide long-term histone replacement in postmitotic cells, including …

Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …

Nucleosome dynamics and properties are central to all forms of genomic activities. Among
the core histones, H3 variants play a pivotal role in modulating nucleosome structure and …

In postmitotic neurons, nucleosomal turnover was long considered to be a static process that
is inconsequential to transcription. However, our recent studies in human and rodent brain …

Histone proteins affect gene expression through multiple mechanisms, including through
exchange with histone variants. Recent findings link histone variants to neurological …

During the brain development, the process of neural stem cells (NSCs) proliferation and
differentiation is precisely regulated. The deficiency in the embryonic brain development will …

H3. 3 is a histone variant that marks transcription start sites as well as telomeres and
heterochromatic sites on the genome. The presence of H3. 3 is thought to positively …

Background The histone variant H3. 3 plays a critical role in maintaining the pluripotency of
embryonic stem cells (ESCs) by regulating gene expression programs important for lineage …

Rat brain cortical neurons originate from germinal cells during a period of 6 days
immediately before birth. Upon leaving the proliferative layer neurons become irreversibly …

Chromatin is a critical regulator of neural plasticity, but basic principles of chromatin function
in neurons are unclear. In this issue of Neuron, Maze et al.(2015) establish histone H3. 3 …