The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

The kynurenine pathway (KP), which is activated in times of stress and infection has been
implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation …

Under physiological conditions 95% of the ingested essential amino acid tryptophan is
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …

Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have
been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …

The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …

Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp)
degradation are reviewed. The KP accounts for~ 95% of dietary Trp degradation, of which …

The kynurenine pathway (KP) is the major catabolic pathway for the essential amino acid
tryptophan leading to he production of nicotinamide adenine dinucleotide. In inflammatory …

Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …