SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1

S Zhang, J Wang, L Wang, S Aliyari… - Cellular & molecular …, 2022 - nature.com
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …

[PDF][PDF] Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

PAC Wing, TP Keeley, X Zhuang, JY Lee… - Cell reports, 2021 - cell.com
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more
than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

PAC Wing, M Prange-Barczynska, A Cross… - PLoS …, 2022 - journals.plos.org
Understanding the host pathways that define susceptibility to Severe-acute-respiratory-
syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of …

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

MZ Hasan, S Islam, K Matsumoto, T Kawai - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged as a
pandemic. Paucity of information concerning the virus and therapeutic interventions have …

How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but …

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

JY Li, CH Liao, Q Wang, YJ Tan, R Luo, Y Qiu, XY Ge - Virus research, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human
coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019 …

[PDF][PDF] Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy

P Conti, A Caraffa, CE Gallenga, R Ross… - J Biol Regul Homeost …, 2020 - researchgate.net
SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-
inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …