Hypoxia-inducible factor (HIF): The link between obesity and COVID-19

A AbdelMassih, E Yacoub, RJ Husseiny, A Kamel… - Obesity Medicine, 2021 - Elsevier
The COVID-19 death toll has involved to date more than 1 million confirmed deaths. The
death rate is even higher in the obese COVID-19 patients, as a result of hypoxia, due to the …

[PDF][PDF] Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis

AC Codo, GG Davanzo, L de Brito Monteiro… - Cell metabolism, 2020 - cell.com
COVID-19 can result in severe lung injury. It remained to be determined why diabetic
individuals with uncontrolled glucose levels are more prone to develop the severe form of …

[HTML][HTML] Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

CM Su, L Wang, D Yoo - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for
coronavirus disease 2019 (COVID-19) that emerged in human populations recently …

Viral mimicry of interleukin-17A by SARS-CoV-2 ORF8

X Wu, T Xia, WJ Shin, KM Yu, W Jung, A Herrmann… - MBio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers cytokine-
mediated inflammation, leading to a myriad of clinical presentations in COVID-19. The SARS …

Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

HIF‐1, the Warburg effect, and macrophage/microglia polarization potential role in COVID‐19 pathogenesis

E Ferraro, M Germanò, R Mollace… - Oxidative Medicine …, 2021 - Wiley Online Library
Despite the international scientific community's commitment to improve clinical knowledge
about coronavirus disease 2019 (COVID‐19), knowledge regarding molecular details …

Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications

P An, YZ Zhu, L Yang - Pharmacological research, 2020 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19) has sparked a global pandemic, affecting
more than 4 million people worldwide. The severe acute respiratory syndrome coronavirus 2 …

Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications

D Singh, H Wasan, KH Reeta - Free Radical Biology and Medicine, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) continues to infect hundred thousands of people …

Targeting cytokine storm to manage patients with COVID-19: a mini-review

N Roshanravan, F Seif, A Ostadrahimi… - Archives of medical …, 2020 - Elsevier
Corona Virus Disease 2019 (COVID-19) pandemic is rapidly spreading all over the world.
Excessive immune responses trigger life-threatening cytokine release syndrome (CRS) …

Overly exuberant innate immune response to SARS-CoV-2 infection

Z Zhou, L Ren, LI Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - 2020 - papers.ssrn.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection has posed a severe threat to global public health. It is unclear how the human …