Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection

P Majumdar, S Niyogi - Epidemiology & Infection, 2020 - cambridge.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently caused acute
respiratory distress syndrome affecting more than 200 countries with varied mortality rate …

[HTML][HTML] Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

E Wyler, K Mösbauer, V Franke, A Diag, LT Gottula… - IScience, 2021 - cell.com
Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …

SARS-CoV-2 accessory protein ORF7b mediates tumor necrosis factor-α-induced apoptosis in cells

R Yang, Q Zhao, J Rao, F Zeng, S Yuan, M Ji… - Frontiers in …, 2021 - frontiersin.org
The accessory proteins of coronaviruses are essential for virus–host interactions and the
modulation of host immune responses. It has been reported that accessory protein ORF3a …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in
December 2019, has caused a large global pandemic and poses a serious threat to public …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling …

L Han, MW Zhuang, J Deng, Y Zheng… - Journal of medical …, 2021 - Wiley Online Library
The suppression of types I and III interferon (IFN) responses by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus …

Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytes

Z Zhou, C Huang, Z Zhou, Z Huang, L Su, S Kang… - IScience, 2021 - cell.com
Dysregulated immune cell responses have been linked to the severity of coronavirus
disease 2019 (COVID-19), but the specific viral factors of severe acute respiratory syndrome …

The immune system and COVID-19: Friend or foe?

F Yazdanpanah, MR Hamblin, N Rezaei - Life sciences, 2020 - Elsevier
Abstract Aim Coronavirus disease 2019 (COVID-19) is a novel highly contagious infection
caused by SARS-CoV-2, which has been became a global public health challenge. The …

Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes
coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has …